RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
let-7i-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
rattus norvegicus
Detection Methods
lncRNA sequence analysis; miRNA-target prediction of MRAK088388 and MRAK081523; qRT-PCR etc.
Target
N4bp2; Plxna4
Pathway
NA
PubMed ID
Title
Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis
Year
2014
Function
"MRAK088388 and MRAK081523 were analysed as long-intergenic non-coding RNAs (lincRNAs), and identified as orthologues of mouse lncRNAs AK088388 and AK081523, respectively. They were significantly up-regulated in BLM-induced pulmonary fibrosis model, and located in the cytoplasm of interstitial lung cells. MRAK088388 and MRAK081523 could regulate N4bp2 and Plxna4 expression by sponging miR-29b-3p and let-7i-5p, respectively, and possessed regulatory functions as ceRNAs."